Shift Work Schedules Accelerate Cognitive Decline at Middle Age

Summary A study by researchers at Texas A&M University College of Medicine has found that shift work schedules causing circadian rhythm dysregulation during early adulthood can accelerate cognitive decline in middle age. Using an animal model, the study revealed that disruptions in circadian rhythms led to earlier memory and learning deficits and long-term neuroinflammation. These…

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Harmony Highlights 2025 Key Catalysts as Wakix Revenue Grows 23%

Summary: Harmony Biosciences reported preliminary revenue for 2024, with Wakix generating $714 million, a 23% increase from 2023. The company outlined its 2025 key catalysts, including an FDA decision on pitolisant for idiopathic hypersomnia, the initiation of a pivotal trial for Pitolisant-HD in narcolepsy, and preclinical data for BP1.15205, an OX2R agonist. These milestones reflect…

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Patch-Based Home Sleep Test Shown to Match In-Lab PSG

Summary: A multicenter validation study has shown that the Onera Sleep Test System (STS), a patch-based home sleep test, performs comparably to gold-standard in-lab polysomnography (PSG) for sleep staging and respiratory event detection. Conducted across seven clinical sites in Germany and a core laboratory at Johns Hopkins University, the study demonstrated high concordance between Onera…

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Collaboration Combines Genomics and Sleep Data to Develop Precision Sleep

Summary: Human Longevity Inc and SleepScore Labs have partnered to integrate whole genome sequencing with advanced sleep data, aiming to deliver highly personalized sleep programs. This collaboration leverages Human Longevity’s genomic analysis capabilities and SleepScore’s extensive sleep datasets to create algorithms that optimize sleep and promote overall health. The precision sleep program, set to launch…

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