February 20, 2025

By Mikal Williams, RPSGT, RST, BSBA Summary: Sleep disturbances in dementia and Parkinson’s disease are both a symptom and a contributing factor to disease progression, as neurodegenerative changes disrupt circadian rhythms, melatonin production, and motor control, while poor sleep accelerates cognitive decline, neuroinflammation, and oxidative stress. Addressing sleep through consistent routines, environmental adjustments, physical activity,…

Harmony Biosciences Holdings Inc has received a refusal to file letter from the US Food and Drug Administration (FDA) for pitolisant for the treatment of excessive daytime sleepiness in adult patients with idiopathic hypersomnia (IH). According to the FDA, a refusal to file “is not a final determination concerning potential approvability or the scientific/medical merits…